WHY CAN BREVICILLIN® DROPS BE STORED OUTSIDE THE REFRIGERATOR?

The simple science that protects a delicate probiotic

When people think about probiotics—especially PharmExtracta precision probiotics—the first thought is often: “They need to be kept in the fridge.”
And in many cases, that is true. Cold storage is essential to preserve the vitality of beneficial bacteria, which are often sensitive to humidity and temperature fluctuations.

With Brevicillin® Drops, however, the situation is different. Its formulation has been specifically designed to remain stable at room temperature, without losing efficacy or probiotic load. The secret? Sunflower oil—an ingredient that is as simple as it is valuable.

Oil keeps probiotics stable

Oil contains no water. This characteristic provides one of the best possible protections for probiotics:

• it prevents bacterial cells from being rehydrated by external humidity
• it keeps the bacteria in a stable dormant state
• it limits temperature-related damage, making them more resistant to occasional heat

In practice, the oil creates a small “protective armor” around the probiotics, helping them remain alive and viable for longer, without the need for refrigeration.

As a result, Brevicillin® Drops can be safely stored outside the refrigerator, even after opening.

What happens if it is stored in the fridge?

At low temperatures, sunflower oil tends to become thicker and partially solidify, temporarily separate from the phase containing the probiotics, and make drop dosing less uniform.

There is nothing to worry about. If the bottle has been kept in the refrigerator, simply hold it in your hands for a few minutes and then shake it carefully before use. It will return to a perfectly homogeneous consistency.

It is also important to remember that, even at room temperature, the probiotic component may settle at the bottom over time. For this reason, always shake before use to resuspend the probiotics evenly.

An essential formulation, designed for children

Brevicillin® Drops are designed to support the youngest patients—even newborns—during times when the intestinal flora needs protection and support, especially during antibiotic therapy with amoxicillin or amoxicillin/clavulanic acid.

The formula is minimal and highly tolerable:

• sunflower oil
• Bifidobacterium breve PRL2020
• stabilizer: mono- and diglycerides of fatty acids

There are no sugars, no flavorings, and no unnecessary ingredients—only what is truly needed.

Why Bifidobacterium breve PRL2020?

Choosing the right probiotic strain is essential, and Bifidobacterium breve PRL2020 is particularly well suited for pediatric use.

Bifidobacteria are the main inhabitants of the infant gut in the first years of life. This is where they naturally belong and where they can best perform their protective functions.

By contrast, many probiotics on the market contain microorganisms that play a less central role in the infant microbiota: lactobacilli that are more prevalent in other body sites, such as the vaginal microbiota, or yeasts with different functions. Useful, certainly, but not the key players in the gut of young children.

Bifidobacteria, instead, are truly “at home” in the child’s intestine. They support digestion of breast milk, contribute to proper immune system development, protect against the overgrowth of undesirable bacteria, and work together with other “friendly bacteria” to maintain balance and eubiosis.

Among them, B. breve is a key species for infant health. PRL2020 also has an additional advantage: it survives the antibiotics amoxicillin and amoxicillin/clavulanic acid. This means it can continue to exert its beneficial role even when the child is taking precisely those drugs that pose the greatest risk of depleting the intestinal flora.

A small dose… for a big benefit

Each drop contains 1 billion live, viable cells. One full dose consists of 5 drops, corresponding to 5 billion probiotics.

The suggested intake during therapy with amoxicillin or amoxicillin/clavulanic acid is 5 drops after each antibiotic dose.

This makes Brevicillin® Drops easy to administer, even to newborns, ensures precise dosing, and makes them ideal for use alongside therapies based on amoxicillin or amoxicillin/clavulanic acid.

Amoxicillin and amoxicillin/clavulanic acid are essential antibiotics in pediatric clinical practice, but they can significantly reduce intestinal bifidobacteria—precisely the microorganisms that are most important for children. This imbalance can increase the risk of dysbiosis and promote intestinal symptoms such as diarrhea, bloating, and irregular bowel movements.

Thanks to the natural resistance of the PRL2020 strain to these antibiotics, Brevicillin® Drops continue to act while therapy is ongoing, helping to maintain balance in the intestinal bacterial flora.

In conclusion

Brevicillin® Drops are a precision probiotic designed for the gut of young children: stable outside the refrigerator, highly concentrated, easy to use even in newborns, and formulated with an exclusive strain selected specifically to be taken alongside the most commonly prescribed antibiotic therapies.

A simple yet advanced choice to care for children’s microbiota when they need it most.