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PRECISION PROBIOTICS AND ANTIBIOTICS TOGETHER: A CHOICE THAT BENEFITS THE GUT

When you take an antibiotic—especially for several days—your gut feels it.

Nausea, stomach pain, irregular bowel movements, and sometimes even urogenital disturbances such as candidiasis are fairly common side effects.
Antibiotics, while essential to fight infection, do not distinguish between “good” and “bad” microbes: they also act on the intestinal microbiota, weakening its balance.

This condition is what physicians refer to as dysbiosis.

Today, however, we know that there is a solution: pairing the antibiotic with the right probiotic.

The clinical study that confirms it

A recent randomized clinical study in adult patients undergoing surgical extraction of wisdom teeth evaluated the impact of co-administration of Bifidobacterium breve PRL2020 together with amoxicillin or amoxicillin/clavulanic acid.

The results are clear:

  • –64% gastrointestinal disorders
  • –100% urogenital disorders

at day 14 after therapy, in patients taking antibiotic + probiotic, compared with antibiotics alone.

Even two months after the end of treatment, patients who had taken the probiotic showed fewer residual symptoms, confirming better microbiota resilience.

In short: those who took PRL2020 together with the antibiotic felt better before, during, and after treatment.

Why Bifidobacterium breve PRL2020?

The PRL2020 strain has a unique characteristic:
it is resistant to the action of the beta-lactam antibiotics most commonly prescribed in dentistry and pediatrics—namely amoxicillin and amoxicillin/clavulanic acid.

This means it remains active in the gut while the antibiotic is doing its job, continuing to:
✔ promote microbiota balance
✔ support the intestinal barrier
✔ counter the proliferation of undesirable microorganisms
✔ reduce the risk of diarrhea, bloating, and nausea

The advantage is concrete and immediate: the antibiotic treats, the probiotic protects.

A more tolerable approach for everyone

According to the study, the probiotic–antibiotic combination proved particularly useful in patients who are more sensitive to dysbiosis or who have had previous adverse reactions to antibiotics.

And it’s not just about “feeling better”:
any treatment that reduces side effects improves adherence to therapy and the quality of post-operative recovery.

In practical terms: when patients feel better, they heal better.

The value of intelligent co-administration

Not all probiotics are the same.
What is needed is a strain that is:
🔹 scientifically selected
🔹 resistant to the prescribed antibiotics
🔹 suited to the human gut

  1. breve PRL2020 fully meets these requirements.

This explains why it is included in the Brevicillin® formulation, specifically designed for supplementation during antibiotic therapy.

In conclusion

Adding a probiotic is not an extra—it is a way to:
✨ keep the microbiota more balanced during treatment
✨ reduce the most bothersome side effects
✨ support gut well-being even after therapy

Science confirms it: antibiotic + PRL2020 = better tolerability, better recovery.

* Mancabelli L, Mancino W, Lugli GA, Argentini C, Longhi G, Milani C, Viappiani A, Anzalone R, Bernasconi S, van Sinderen D, Ventura M, Turroni F. Amoxicillin-Clavulanic Acid Resistance in the Genus Bifidobacterium. Appl Environ Microbiol. 2021 Mar 11;87(7):e03137-20. doi: 10.1128/AEM.03137-20. PMID: 33483308; PMCID: PMC8091617.